Osteoporosis therapy using nanoparticles: a review
Soumeia Zeghoud, Ilham Ben Amor, Ali Alnazza Alhamad, Lamis R. Darwish, Hadia Hemmami
Abstract
Osteoporosis, characterized by low bone density and increased risk of fractures, represents a major healthcare challenge. Anti-resorptive and anabolic medications are now used to treat osteoporosis in an effort to reduce bone loss and increase bone mass. Innovative methods are required since current therapies have drawbacks. Promising options for improving bone health and medicine delivery are provided by nanotechnology. Bisphosphonates with tetracyclines and oligopeptides, among other compounds that target the bone, make it easier to provide a particular medication to bone tissue. Additionally, nanocarriers are essential for the administration of both organic and inorganic nanoparticles in the treatment of osteoporosis. Drug encapsulation and controlled release may be done in a variety of ways using organic nanoparticles. Inorganic nanoparticles have special qualities that help in medication transport and bone repair. This review explores the potential of nanoparticle-based strategies in the treatment of osteoporosis.
Details
| Original language | English |
|---|---|
| Journal | Annals of Medicine and Surgery |
| Volume | 86 |
| Issue number | 1 |
| Pages | 284-291 |
| Publisher | Wolters Kluwer |
| ISSN | 2049-0801 |
| DOI | 10.1097/ms9.0000000000001467 |
| Publication status | Published — 1 November 2023 |
Keywords
UN Sustainable Development Goals
- 3 — Good health and well-being
Fingerprint
- Bone health and osteoporosis research
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- osteoporosis
- nanoparticle drug delivery
- nanocarriers
- bisphosphonates
- tetracycline
- oligopeptides
- antiresorptive therapy
- bone anabolic therapy
- Orthopedics and Sports Medicine
- Biomedical Engineering
- Molecular Biology
- Medicine
- Engineering
- Biochemistry, Genetics and Molecular Biology