Unveiling the Therapeutic Potential of Atractylis aristata Batt. Aqueous Extract: Anti‐inflammatory, Antioxidant, Antibacterial, Sedative Activities & Phytochemical Profiling
Asma Abid✉، Nourelhouda Mekhadmi، Randa Mlik، Assia Bentahar، Kamilia Bireche، Bariza Frih، Walid Boussebaa، Aicha Mouane، Nezar Cherrada، Ana T. Sanches-Silva، Messaouda Dekmouche، Lazhar Bechki، Khalid Mashay Al‐Anazi، Mohammad Abul Farah، Ahmad Ali
الملخّص
Abstract Medicinal plants possess the potential to yield bioactive compounds that offer significant health benefits; positioning them as valuable and promising sources for the development of innovative pharmaceutical products. This study aims to comprehensively assess the in vitro and in vivo pharmacological effects of the aqueous extract of the plant Atractylis aristata (AEAA) as well as assessments of its phytochemical composition. UPLC‐ESI‐MS/MS analysis of AEAA revealed a variety of bioactive compounds, including flavonoids and phenolic acids. In antioxidant assays, AEAA demonstrated considerable activity, with IC 50 values of 0.269±0.05 mg/mL for DPPH scavenging and 0.0376±0.003 mg/mL for hydrogen peroxide radical inhibition. AEAA exhibited strong anti‐inflammatory activity in vitro , with an IC 50 value of 2.563 mg/mL in the BSA denaturation test. In vivo , AEAA reduced carrageenan‐induced paw edema by 56.51 %, in comparison to an 83.58 % reduction with Ibuprofen®. Antibacterial testing showed AEAA′s broad‐spectrum activity, with the highest inhibition against Bacillus subtilis (34 mm zone of inhibition). Additionally, AEAA induced significant sedative effects, reducing locomotor activity by 48.98 %. These findings underscore the diverse pharmacological potential in addressing oxidative stress, inflammation, microbial infections, and anxiety of A. aristata , which can be attributed to its rich phytochemical profile.
التفاصيل
| اللغة الأصلية | English |
|---|---|
| المجلّة | ChemistryOpen |
| المجلّد | 14 |
| العدد | 9 |
| الصفحات | e202500056 |
| الناشر | WileyOpen |
| ISSN | 2191-1363 |
| DOI | 10.1002/open.202500056 |
| حالة النشر | منشور — 17 أفريل 2025 |
الكلمات المفتاحية
أهداف التنمية المستدامة
- 3 — الصحة الجيدة والرفاه
البصمة
- Medicinal Plant Research
- Phytochemistry and Biological Activities
- Medicinal Plant Extracts Effects
- aqueous plant extract
- anti-inflammatory activity
- antioxidant activity
- antibacterial activity
- sedative effects
- phytochemical profiling
- flavonoids
- phenolic acids
- Plant Science
- Complementary and alternative medicine
- Agricultural and Biological Sciences
- Medicine