Matricaria pubescens (DESF.) SCH. essential oils and their potential to inhibit several critical enzymes linked to type II diabetes and Alzheimer’s disease and antimicrobial activity

Matricaria pubescens is an aromatic plant endemic to South Algeria. The aim of this study was to investigate the anti-cholinesterase and anti-diabetic activity of M. pubescens essential oils (MPEOs) and to correlate the activity with their chemical composition. The analysis of essential oils was conducted using GC-MS. One of the main components identified was α-pinene, ranging from 9.85% to 20.46%, along with D-limonene at 2.52-5.62%, and β-ocimene at 18.99-35.52%. Significant inhibitory activity was detected and considered potent as cholinesterase inhibitor (Acetylcholinesterase IC50 = 13.91 ± 1.14 μg/mL and butyrylcholinesterase IC50 = 11.25 to 20.01 μg/mL). Also, MPEOs exhibited the ability as a potent inhibitors of α-glucosidase (IC50 = 50.07 ± 3.71 μg/mL) and α-amylase (IC50 = 12.96 ± 0.51 μg/mL). This study demonstrated that MPEOs may provide a new alternative source of antidiabetic and anti-Alzheimer’s activities and that further experiments are needed to investigate the main active compounds.

• essential oils
• anticholinesterase activity
• acetylcholinesterase inhibition
• butyrylcholinesterase inhibition
• α-glucosidase inhibition
• α-amylase inhibition
• antidiabetic activity
• anti-Alzheimer's activity
• α-pinene
• β-ocimene
• D-limonene
• essential oil composition
• antimicrobial activity

• 3 — الصحة الجيدة والرفاه

• Essential Oils and Antimicrobial Activity
• Natural Antidiabetic Agents Studies
• Phytochemistry and Biological Activities
• essential oils
• anticholinesterase activity
• acetylcholinesterase inhibition
• butyrylcholinesterase inhibition
• α-glucosidase inhibition
• α-amylase inhibition
• antidiabetic activity
• anti-Alzheimer's activity
• Food Science
• Endocrinology, Diabetes and Metabolism
• Plant Science
• Agricultural and Biological Sciences
• Medicine